Vast by Linda Nagata (1998)Read about the other entries on the list at Tor.com.
The alien Chenzeme littered swaths of the Milky Way with ancient but still functional war machines. Although the war that spawned them is long over, the machines are perfectly happy to target humans who encounter the homicidal relics. Some human ships escape; most of them are eradicated.
The starship Null Boundary was lucky enough to survive an encounter with Chenzeme relics. Now the craft flees towards what the crew hopes will be answers, pursued by a relentless relic. Stern chases are long chases, particularly where sublight interstellar vehicles are concerned. Mortal humans might well die of old age mid-voyage. Mind-recording is only one of the marvelous technologies humanity has mastered, but it is the one that proves most useful to the crew of the Null Boundary.
--Marshal Zeringue