One Hundred Years of Solitude by Gabriel García Márquez (1967)Read about the other entries on the list.
Like [Junot Díaz's] Oscar Wao, this is another novel that features a generational curse, though the source of the curse can be specifically pin-pointed. Early in the story, one of the characters (Ursula’s mother) warns that a baby born from incest will have the tail of a pig. As the family enters the modern era (or, as the modern era encroaches upon the family), the family morally deteriorates until finally, the prophecy is fulfilled, leaving the pig-tailed baby to be abandoned and eventually eaten by ants. The generational curse is then broken because the family itself is broken.
One Hundred Years of Solitude made Sameer Rahim's list of five essential works by Gabriel García Márquez, Isabel Allende's list of six favorite books, Sara Jonsson's list of five books to read when you can't go to sleep, Juan Gabriel Vásquez's five best list of novels about South America, Pushpinder Khaneka's list of three of the best books on Colombia, Michael Jacobs's list of the top ten Colombian stories, Simon Mason's top ten list of fictional families and Rebecca Stott's five best list of historical novels. It is one of Lynda Bellingham's six best books, Walter Mosley's five favorite books, Eric Kraft's five most important books, and James Patterson's five most important books.