Miss Lonelyhearts by Nathanael WestRead about the other entries on the list.
This black comedy set in Depression-era Manhattan follows the career of a cynical advice columnist who struggles to find a moral compass while dispensing trite advice, under the name Miss Lonelyhearts, to desperate city dwellers. It's film noir with a laugh track.
Miss Lonelyhearts is among Fay Weldon's six favorite books and Ann Patchett's most important books.
--Marshal Zeringue